Investigating the combined effects of smoking and amyloid on brain structure in cognitively unimpaired adults using a machine learning‐based MRI marker

These findings suggest a complex relationship between smoking, amyloid pathology, and cognition. The observation that SPARE-SM differed by Aβ in smoking individuals highlights their potential synergistic effects on neurodegeneration. SPARE-SM demonstrated associations with cognitive decline, even when clinical smoking status did not, emphasizing its potential for early risk identification. Further research is needed to disentangle the mechanisms linking smoking, brain changes, amyloid, and dementia.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70862_110097
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Investigating the combined effects of smoking and amyloid on brain structure in cognitively unimpaired adults using a machine learning‐based MRI marker

Ilya M. Nasrallah, Christos A. Davatzikos, Dhivya Srinivasan, Randa Melhem et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Investigating the combined effects of smoking and amyloid on brain structure in cognitively unimpaired adults using a machine learning‐based MRI marker

Ilya M. Nasrallah, Christos A. Davatzikos, Dhivya Srinivasan, Randa Melhem, Haochang Shou, Sindhuja Tirumalai Govindarajan, Elizabeth Mamourian, Guray Erus
article en

Abstract

These findings suggest a complex relationship between smoking, amyloid pathology, and cognition. The observation that SPARE-SM differed by Aβ in smoking individuals highlights their potential synergistic effects on neurodegeneration. SPARE-SM demonstrated associations with cognitive decline, even when clinical smoking status did not, emphasizing its potential for early risk identification. Further research is needed to disentangle the mechanisms linking smoking, brain changes, amyloid, and dementia.

Alzheimer s & DementiaVol. 21(S8)
Intel (United States) (US), Artificial Intelligence in Medicine (Canada) (CA), University of Pennsylvania (US)
Good health and well-being
Openalex Percentile: Top 35%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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Investigating the combined effects of smoking and amyloid on brain structure in cognitively unimpaired adults using a machine learning‐based MRI marker — Ilya M. Nasrallah, Christos A. Davatzikos, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS