Gut microbiota signatures associated with ketogenic diet response in pediatric drug-resistant epilepsy

Higher baseline abundances of Lachnoclostridium and Barnesiella were identified as potential predictive biomarkers for favorable KD response in pediatric DRE. The dynamic increases in Parabacteroides and Akkermansia during KD intervention further distinguished responders, whereas elevated Catenibacterium levels were associated with poor treatment outcomes, providing preliminary insights for treatment stratification.