Microglial proteomic signature in human CSF allows stratification by APOE genotypes and is replicated in iPSC‐based model
Using proteomics as readout, this study demonstrates the translational value of iPSC-derived models and proofs its value to assess mechanisms of function to better understand how APOE confers risk or protection for AD.
Authors
- Asif Imran Emon (ORCID: https://orcid.org/0000-0002-2331-5174)
- María Eugenia Sáez (ORCID: https://orcid.org/0000-0001-9299-2534)
- Carlos C Cruchaga
- Pablo García‐González (ORCID: https://orcid.org/0000-0003-0125-5403)
- Bart Smets (ORCID: https://orcid.org/0000-0001-8480-0782)
- Agustín Ruiz
- Mercè Boada
- Alfredo Cabrera Socorro
- Amanda Cano
- Raquel Puerta
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- University of Wuppertal (DE)
- Washington University in St. Louis (US)
- Universitat Internacional de Catalunya (ES)
- Centro Andaluz de Biología del Desarrollo (ES)
- Fundació ACE (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108563
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00