Traffic‐related air pollution significantly aggravates the detrimental impact of infections on the risk of Alzheimer's disease, particularly in non‐carriers of APOE4
Chronically high exposure to TRAP significantly aggravates the detrimental impact of infections on the risk of AD and other dementias in males and females aged 60-75 years, particularly in non-carriers of APOE4. Weaker associations in APOE4 carriers may be explained by APOE4 being a very strong AD risk factor, whose AD-promoting effects may outweigh the effects of other risk factors.
Authors
- Svetlana Ukraintseva (ORCID: https://orcid.org/0000-0002-0079-5494)
- Igor Akushevich (ORCID: https://orcid.org/0000-0003-3471-7846)
- Konstantin G. Arbeev (ORCID: https://orcid.org/0000-0002-4195-7832)
- Arseniy Yashkin (ORCID: https://orcid.org/0000-0002-1185-148X)
- V. Popov
- Anatoliy Yashin
- Hongzhe Duan
Institutions
- Social Science Research Council (US)
- Duke University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_104117
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00