Seizures worsen tau spread preferentially in hyperactive neurons in a murine tauopathy model

Together, these results demonstrate a bidirectional relationship between neuronal hyperactivity and tau pathology, and suggest seizures and seizure activated neurons as targets to slow progression of tau pathology.

Authors

Aaron J Barbour (ORCID: https://orcid.org/0000-0002-4880-6797)
Frances E. Jensen
Virginia M. M.‐Y. Lee
Keegan Hoag
Delia M Talos

Institutions

University of Pennsylvania (US)

Publication Details

Journal: Alzheimer s & Dementia
Published: 2025-12-01
DOI: https://doi.org/10.1002/alz70861_108774
Primary Topic: Alzheimer's disease research and treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

Seizures worsen tau spread preferentially in hyperactive neurons in a murine tauopathy model

Aaron J Barbour, Frances E. Jensen, Virginia M. M.‐Y. Lee, Keegan Hoag et al.

Dec 1, 2025

Alzheimer s & Dementia

Alzheimer's disease research and treatments

article

Seizures worsen tau spread preferentially in hyperactive neurons in a murine tauopathy model

Aaron J Barbour, Frances E. Jensen, Virginia M. M.‐Y. Lee, Keegan Hoag, Delia M Talos

December 1, 2025article en

Abstract

Alzheimer s & DementiaVol. 21(S7)

University of Pennsylvania (US)

Openalex Percentile: Top 34%

Alzheimer's disease research and treatments

DOI Open Access PDF OpenAlex

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Seizures worsen tau spread preferentially in hyperactive neurons in a murine tauopathy model — Aaron J Barbour, Frances E. Jensen, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS