Benzodiazepine Use in Middle‐Aged Adults at Risk for AD

These investigations showed that despite the increased risk for dementia in the HBP sample, current BZDR use, with or without concomitant antidepressant use, was not associated with quantitatively defined risk for dementia. Limitations include: 1) cross-sectional nature of the study limited ability to ascertain causality; 2) individuals with major psychiatric conditions were excluded from the study, thus limiting external validity of the current findings; 3) HBP sample has a higher proportion of individuals with a family history of dementia compared to the general population, hence the sample presents with an increased risk of developing dementia and generalizability of our findings may be limited.