Locus coeruleus structural integrity relates to cortical amyloid and tau pathology <i>in vivo</i>
LC degeneration was associated with greater expression of key hallmarks of AD pathology in asymptomatic older adults. We support the model that LC is central to the earliest pathophysiological changes of AD.
Authors
- Colleen Hughes (ORCID: https://orcid.org/0000-0002-0632-4060)
- John C.S. Breitner (ORCID: https://orcid.org/0000-0003-4229-4687)
- Alfie Wearn (ORCID: https://orcid.org/0000-0001-7699-648X)
- Giulia Baracchini (ORCID: https://orcid.org/0000-0001-9198-2780)
- Sylvia Villeneuve (ORCID: https://orcid.org/0000-0003-2338-0467)
- Gary R. Turner (ORCID: https://orcid.org/0000-0001-7232-8994)
- Josée Poirier (ORCID: https://orcid.org/0000-0002-1302-869X)
- Ilana R. Leppert (ORCID: https://orcid.org/0000-0001-7672-0918)
- Christine Tardif
- R. Nathan Spreng
Institutions
- Montreal Neurological Institute and Hospital (CA)
- The University of Sydney (AU)
- York University (CA)
- Douglas Mental Health University Institute (CA)
- McGill University Health Centre (CA)
- McGill Genome Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110106
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00