Estimating Early Biomarker Accelerations in AD‐progression: Modelling the Jack Curves
Late AD-progression and covariate-related shifts in progression were comparable across models, suggesting robustness to sigmoid choice. In contrast, estimates of early AD-onset may be more dependent on functional form. While logistic-sigmoids inherently increase monotonically, hyperbolas do not, here estimating a decline in initial amyloid trend. Future work may explore adding biologically informed constraints to flexible sigmoidal-functions, and alternative Bayesian approaches, to optimize both model fit and estimation of early AD-onset age.
Authors
- Petrice M. Cogswell (ORCID: https://orcid.org/0000-0002-8128-4476)
- D. S. Knopman
- Jonathan Graff‐Radford
- TH Mosley
- Gwen Windham
- Murat Bilgel (ORCID: https://orcid.org/0000-0001-5042-7422)
- Jeannette Simino
- M E Griswold
- C. R. Jack
- Hunter C Sylvester
- Ronald Petersen
- Prashanthi Vemuri
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- Mayo Clinic in Arizona (US)
- Institute on Aging (US)
- National Institute on Aging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108869
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00