Loss, amplification or mistiming of the daily rhythms of metabolic markers in patients with cirrhosis

This study demonstrates significant disruptions in the daily rhythms of plasma metabolites in patients with cirrhosis that parallel disease severity. Although the underlying mechanisms and direct clinical consequences of these rhythm disturbances require further investigation, their potential long-term effects are likely to be important, particularly in the context of metabolic and nutritional health in this patient population. These findings highlight the need to consider temporal dynamics in both the assessment and management of cirrhosis and may inform future strategies for chronotherapy, dietary interventions, and personalized care.