Drug-Drug Interaction between Toosendanin and Tamoxifen and Its Potential Mechanism

This study demonstrates that toosendanin alters the pharmacokinetics of tamoxifen, likely by inhibiting its metabolic stability and CYP2D6 activity. This interaction leads to a potentially significant pharmacokinetic risk when toosendanin is co-administered with tamoxifen, potentially potentiating its exposure.

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Publication Details

Journal
Chemotherapy
Published
2025-12-23
DOI
https://doi.org/10.1159/000550093
Primary Topic
Phytochemistry and Bioactive Compounds
Type
article
Field-Weighted Citation Impact
0.00
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article

Drug-Drug Interaction between Toosendanin and Tamoxifen and Its Potential Mechanism

Ting Lin, Pingfa Lin, Yirong Zhen, Xiao He et al.
Chemotherapy
Phytochemistry and Bioactive Compounds
article

Drug-Drug Interaction between Toosendanin and Tamoxifen and Its Potential Mechanism

Ting Lin, Pingfa Lin, Yirong Zhen, Xiao He, Ying Chang
article en

Abstract

This study demonstrates that toosendanin alters the pharmacokinetics of tamoxifen, likely by inhibiting its metabolic stability and CYP2D6 activity. This interaction leads to a potentially significant pharmacokinetic risk when toosendanin is co-administered with tamoxifen, potentially potentiating its exposure.

Chemotherapy
Fujian Medical University (CN), 117th Hospital of People's Liberation Army (CN), Education Department of Fujian Province (CN), 82th Hospital of Pla (CN), Fujian Provincial Hospital (CN), Fuzhou University (CN)
Good health and well-being
Openalex Percentile: Top 44%
Phytochemistry and Bioactive Compounds
DOISourceOpenAlex
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Drug-Drug Interaction between Toosendanin and Tamoxifen and Its Potential Mechanism — Ting Lin, Pingfa Lin, et al. · Chemotherapy (2025) | TGRS Research Map | TGRS