Whole‐brain cell‐cell interaction patterns explain tissue damage in several neurodegenerative conditions
We identified whole-brain ligand-receptor interactions involved in neuron-astrocyte, neuron-microglia, and neuron-neuron signaling pathways that explain the observed atrophy patterns in multiple neurodegenerative conditions. These key ligands and receptors may serve as potential therapeutic targets and advance our understanding of neurodegeneration.
Authors
- Mahsa Dadar (ORCID: https://orcid.org/0000-0003-4008-2672)
- Veronika Pak (ORCID: https://orcid.org/0009-0008-6305-2541)
- Yashar Zeighami
- Gleb Bezgin
- Joon Hwan Hong
- Yasser Iturria Medina
Institutions
- Montreal Neurological Institute and Hospital (CA)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109795
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00