Myocardial sympathetic distal axon loss in subjects with Lewy pathology: an artificial intelligence‐based histopathological analysis
Lewy pathology in the central nervous system is strongly associated with loss of sympathetic distal axons at the myocardial level. The body-first LBD subtype is one of the strongest predictors of myocardial sympathetic denervation in the oldest-old population.
Authors
- Maarit Tanskanen
- Anders Paetau
- Anna Raunio (ORCID: https://orcid.org/0000-0003-0356-7048)
- Henri Puttonen (ORCID: https://orcid.org/0000-0002-8059-8457)
- Jarno Tuimala
- Ville Kivistö
- Maria K. Lehtinen (ORCID: https://orcid.org/0000-0002-7243-2967)
- E K Ahvenainen
- Olli Tynninen
- Benjamin Englert (ORCID: https://orcid.org/0000-0002-1769-5393)
- Kia Colangelo
- Tuomo Polvikoski
- Liisa Myllykangas (ORCID: https://orcid.org/0000-0002-2237-5466)
- Pekka J. Karhunen (ORCID: https://orcid.org/0000-0002-0320-571X)
- Karri Kaivola (ORCID: https://orcid.org/0000-0003-1218-4014)
- Dilip Kumar (ORCID: https://orcid.org/0000-0003-4858-8440)
- Pentti J. Tienari (ORCID: https://orcid.org/0000-0001-5686-2900)
- Sara Savola (ORCID: https://orcid.org/0000-0003-1940-2627)
- Mikko I. Mäyränpää
- Per Borghammer
- Eloise H Kok
Institutions
- Boston Children's Hospital (US)
- University of Helsinki (FI)
- Harvard University (US)
- Tampere University (FI)
- Helsinki University Hospital (FI)
- Aarhus University Hospital (DK)
- Fimlab (Finland) (FI)
- Hospital District of Helsinki and Uusimaa (FI)
- Newcastle University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108548
- Primary Topic
- Takotsubo Cardiomyopathy and Associated Phenomena
- Type
- article
- Field-Weighted Citation Impact
- 0.00