Relationship Between Age and Severity of Cognitive Impairment at Diagnosis For Early‐Onset and Late‐Onset Alzheimer’s Disease: Comparison of LEADS and ADNI

Results suggest a unique relationship between EOAD and LOAD populations for the age at enrollment and cognitive severity for executive and processing/learning domains. This supports previous findings that EOAD manifests clinically in a distinct fashion than LOAD in these domains. In the age of disease-modifying treatments, results highlight the importance of assessing for cognitive declines in individuals starting much earlier than age 65.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70861_108877
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Relationship Between Age and Severity of Cognitive Impairment at Diagnosis For Early‐Onset and Late‐Onset Alzheimer’s Disease: Comparison of LEADS and ADNI

K A Nudelman, Marı́a C. Carrillo, Alex Taurone, Liana G. Apostolova et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Relationship Between Age and Severity of Cognitive Impairment at Diagnosis For Early‐Onset and Late‐Onset Alzheimer’s Disease: Comparison of LEADS and ADNI

K A Nudelman, Marı́a C. Carrillo, Alex Taurone, Liana G. Apostolova, Ani Eloyan, Kala Kirby, Jeffrey L. Dage, Gil D. Rabinovici, Brad C. Dickerson, Maryanne Thangarajah
article en

Abstract

Results suggest a unique relationship between EOAD and LOAD populations for the age at enrollment and cognitive severity for executive and processing/learning domains. This supports previous findings that EOAD manifests clinically in a distinct fashion than LOAD in these domains. In the age of disease-modifying treatments, results highlight the importance of assessing for cognitive declines in individuals starting much earlier than age 65.

Alzheimer s & DementiaVol. 21(S7)
Alzheimer's Association (US), Harvard University (US), University of California, San Francisco (US), Brown University (US), Massachusetts General Hospital (US), University Memory and Aging Center (US), Indiana University School of Medicine, Indiana University – Purdue University Indianapolis (US), Indiana University (US)
Quality Education
Openalex Percentile: Top 35%
Dementia and Cognitive Impairment Research
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