Developing human locus coeruleus organoids to study regional selective vulnerability in Alzheimer's disease
Human LC organoids contain LC-like noradrenergic neurons that show pathogenic alterations when generated from familial AD mutation carriers. Studying the structure and function of LC organoids derived from both healthy controls and AD patients may provide new insights into the role of the LC and biology of selective vulnerability in AD.
Authors
- Fikri Birey (ORCID: https://orcid.org/0000-0003-2632-2764)
- Margaret M. Tish (ORCID: https://orcid.org/0000-0002-8954-1983)
- David Weinshenker (ORCID: https://orcid.org/0000-0002-3678-6215)
- Lauren Gao
- Zihui Ou
Institutions
- Emory University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098441
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00