Tau PET Burden is Associated with Hippocampal Microstructure and Episodic Memory in Older Adults with Amyloid Burden
These findings suggest hippocampal microstructure may be sensitive to AD-related pathological burden and associated neurodegeneration, particularly in the early symptomatic phase, and is associated with tau PET and cognitive decline while accounting for hippocampal volume.
Authors
- Anja Soldan (ORCID: https://orcid.org/0000-0002-6193-0418)
- Kylie H. Alm
- Corinne Pettigrew
- Sara Sheikhbahaei (ORCID: https://orcid.org/0000-0001-7866-4681)
- Daniel D. Callow (ORCID: https://orcid.org/0000-0003-0843-6602)
- Nisha Rani
- Arnold Bakker
- Marilyn S. S. Albert
- Michael I Miller
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Johns Hopkins University Applied Physics Laboratory (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110257
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00