PARP7 and aryl hydrocarbon receptor differentially regulate mammary cancer cell proliferation and STING-induced type I interferon signalling
These findings highlight the complexity of the interplay among PARP7, AHR and STING-induced IFN signalling in regulating cancer cell proliferation but also suggest that for some cell lines STING activation might increase their sensitivity to the anti-proliferative effects of RBN2397.
Authors
- Ninni Elise Olafsen (ORCID: https://orcid.org/0000-0002-4494-3858)
- Samaneh Shabani Åhrling
- Marit Rasmussen (ORCID: https://orcid.org/0000-0003-0763-6725)
- Linnea A. M. Erlingsson
- Akinori Takaoka
- Emma N. Granly
- Jason Matthews
Institutions
- University of Oslo (NO)
- University of Toronto (CA)
- Hokkaido University (JP)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1007/s13402-025-01150-w
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00