The ketamine metabolite ( <i>2R,6R</i> )‐hydroxynorketamine rescues transcriptional pathways involved with immune activation and mRNA translation in APP/PS1 mice
Altogether, these results indicate that HNK rescues transcriptional programs associated with inflammation, impaired proteostasis, calcium signaling, and synaptic proteins in aged APP/S1 mice.
Authors
- Rubens Soares‐Neto (ORCID: https://orcid.org/0000-0002-6708-4312)
- Felipe C. Ribeiro (ORCID: https://orcid.org/0000-0003-3028-3307)
- Mychael V. Lourenco (ORCID: https://orcid.org/0000-0002-1078-0296)
- Ottavio Arancio (ORCID: https://orcid.org/0000-0001-6335-164X)
- Joao D. Calixtro
- Sérgio T. Ferreira (ORCID: https://orcid.org/0000-0001-7160-9866)
- Danielle Cozachenco Ferreira
- Nahum Sonenberg
- Fernanda Guarino De Felice
- Argel Aguilar‐Valles
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Queen's University (CA)
- D’Or Institute for Research and Education (BR)
- McGill University (CA)
- Carleton University (CA)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_099460
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00