HiSTaR: identifying spatial domains with hierarchical spatial transcriptomics variational autoencoder
HiSTaR offers an effective computational tool for spatial transcriptomics research. By capturing hierarchical latent features, it improves spatial domain identification. This framework holds potential to advance understanding of tissue heterogeneity and spatially resolved gene expression patterns.
Authors
- P Xu
- W. Liu
- Jia Yuan (ORCID: https://orcid.org/0000-0001-6497-8305)
- Zheng Ye
- Qianbei Yi
- Junhua Yu
Institutions
- Guangzhou University (CN)
- Qiannan Normal College For Nationalities (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1186/s12967-025-07404-3
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00