Low Serum Albumin Predicts Accelerated Cognitive Decline in Older Adults with Type 2 Diabetes: Effects of APOE4 Genotype
In older adults with T2D, lower serum albumin is linked to faster cognitive decline, particularly in APOE4 carriers. This may result from a compromised BBB in APOE4 carriers, permitting greater albumin leakage into the brain, increasing neurotoxicity and accelerating cognitive decline.
Authors
- Tal Davidy
- Yuxia Ouyang (ORCID: https://orcid.org/0000-0002-2671-6117)
- Ethel Boccara
- Mery Ben‐Meir
- Itzik Cooper (ORCID: https://orcid.org/0000-0003-0723-5542)
- Jack W. Tsao (ORCID: https://orcid.org/0000-0002-7425-8763)
- Yu Gu (ORCID: https://orcid.org/0000-0002-5073-6871)
- Joseph Azuri
- Dar Gelblum
- Michal S Beeri
- Ramit Ravona‐Springer
- Hanadi Shamrok
Institutions
- Rutgers, The State University of New Jersey (US)
- Allen Institute for Brain Science (US)
- Sheba Medical Center (IL)
- Maccabi Healthcare Services (IL)
- New York University (US)
- Columbia University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108645
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00