HAEEPGP Peptide Efficiently Prevents Alzheimer's Disease Pathology <i>in Vivo</i>
We created the stable short peptide HAEEPGP that crossed BBB and specifically bound to Aβ and its isomerized form. HAEEPGP thoroughly inhibited AD-related abnormalities in cultured microglial cells, AD transgenic nematodes, and 5xFAD mice. Thus, HAEEPGP has promising therapeutic potential for AD. Supported by the Russian Science Foundation (grant #19-74-30007).
Authors
- Kirill Chaprov (ORCID: https://orcid.org/0000-0002-0258-1879)
- Vladimir A. Mitkevich (ORCID: https://orcid.org/0000-0002-1517-1983)
- Olga I. Kechko
- Kristina A. Mukhina
- Alexander A. Makarov
- Dmitry Yanvarev
Institutions
- Engelhardt Institute of Molecular Biology (RU)
- Institute of Problems of Chemical Physics (RU)
- Institute of Physiologically Active Compounds (RU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_097997
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00