Dynamic Lifestyle Changes Mitigate Alzheimer's Disease Risk Across Genetic Susceptibility
This study integrated EAA with longitudinal analyses of lifestyle and genetic factors, providing novel insights into the pathways connecting lifestyle changes, genetic susceptibility, and cognition. Our findings underscore the importance of targeted lifestyle interventions in mitigating AD risk even among individuals with high genetic risk, highlight the potential for personalized prevention strategies based on biological aging and genetic profiles.
Authors
- Yasuyuki Taki
- Yingxu Liu (ORCID: https://orcid.org/0000-0002-5053-4911)
- Takuji Kawamura (ORCID: https://orcid.org/0000-0003-2110-8718)
- Kentaro Oba
- Yue Shi
Institutions
- University of Southern California (US)
- Tohoku University (JP)
- Tohoku University Hospital (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_097792
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00