The Impact of Glucagon-Like Peptide-1 Receptor Agonists on Fracture Risk in Overweight or Obese, Nondiabetic Patients
GLP-1RA use was associated with increased fracture risk in nondiabetic patients who were overweight or obese. Subgroup analysis demonstrated that only those with BMI ≥40 and age ≥68 years were found to have a significant increase in fracture risk. Further research is necessary to guide GLP-1RA prescriptions.
Authors
- Alexander Lauder (ORCID: https://orcid.org/0000-0002-5889-0558)
- Emily M. Pflug (ORCID: https://orcid.org/0000-0001-6064-2732)
- Luke F. Enthoven
- Evangelia Constantine
- Riley Kahan
Institutions
- Medical Protective (US)
- Research Institute Orion (UA)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Journal of the American Academy of Orthopaedic Surgeons
- Published
- 2025-12-11
- DOI
- https://doi.org/10.5435/jaaos-d-24-01505
- Citations
- 1
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.29