Implementing robust amyloid PET quantification in multi‐center studies: AMYPAD approach to address data acquisition, processing, interpretation and data sharing challenges
We share AMYPAD's end-to-end approach to amyloid positron emission tomography (PET) quantification from data acquisition and handling, harmonization based on Hoffman phantoms, quality control, image processing, to data storage, and data sharing strategies.Centiloid quantification was compared across one PET-only (AmyPype) and two PET-MR pipelines (standard Centiloid and IXIXO-LEAP). Excellent agreement in dichotomized Centiloid valued was observed both between pipelines and when compared to visual reads.Distribution of Centiloid values in the Prognostic and Natural History Study (PNHS) and Diagnostic and Patient Management Study (DPMS) are in line with the initial recruitment strategies of the trials.Harmonization of Amyloid-PET scans framework was adopted by EARL as the Brain PET/CT accreditation standard for multicentre brain PET scans.
Authors
- Emma S. Luckett (ORCID: https://orcid.org/0000-0003-1777-4742)
- Rossella Gismondi (ORCID: https://orcid.org/0000-0002-0926-5051)
- Ariane Bollack (ORCID: https://orcid.org/0000-0002-9169-7530)
- Paweł Markiewicz (ORCID: https://orcid.org/0000-0002-3114-0773)
- Anja Mett
- A. Drzezga
- Juan Domingo Gispert (ORCID: https://orcid.org/0000-0002-6155-0642)
- Gill Farrar (ORCID: https://orcid.org/0000-0002-0726-723X)
- Pieter Jelle Visser
- Robin Wolz
- Frederik Barkhof
- Mahnaz Shekari
- Christopher Buckley
- Alle Meije Wink
- David Valléz García
- Andrew Stephens
- Lyduine E. Collij
- Maqsood Yaqub
Institutions
- Royal Free London NHS Foundation Trust (GB)
- Universitat Pompeu Fabra (ES)
- Forschungszentrum Jülich (DE)
- Malmö University (SE)
- General Electric (Spain) (ES)
- German Center for Neurodegenerative Diseases (DE)
- Ixico (United Kingdom) (GB)
- Pasqual Maragall Foundation (ES)
- Amsterdam Neuroscience (NL)
- Digital Science (United Kingdom) (GB)
- Barcelonaβeta Brain Research Center (ES)
- National Hospital for Neurology and Neurosurgery (GB)
- University Hospital Cologne (DE)
- Hospital del Mar Research Institute (ES)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/trc2.70190
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Federation of Pharmaceutical Industries and Associations
- European Commission