Systemic inflammatory perturbations triggered by neuropathic pain in L5 compressed mouse and rat model
Our study identifies key genes and signaling pathways that may contribute to systemic inflammation in nerve compression-induced neuropathic pain. We sorted out potential intervention targets to modulate the inflammatory process in neuropathic pain, such as inhibitors of Csf3 and IL13, as well as targeting the IL6/TNF-α pathway. However, further functional validation is necessary to confirm their therapeutic efficacy.
Authors
- Peng Liao (ORCID: https://orcid.org/0000-0002-4583-5285)
- Yigang Huang
- Sihan Tong
- Fang Ye (ORCID: https://orcid.org/0000-0002-1322-7365)
- Junjie Gao (ORCID: https://orcid.org/0000-0001-6869-2013)
- Zhikai Zheng
- Hua Ying
- Zhigang Zhong
- Delin Liu
- Shangmin Chen
- Jian Zhou
Institutions
- Shanghai Jiao Tong University (CN)
- Shantou University (CN)
- Shanghai Ninth People's Hospital (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou University Medical College (CN)
- Shanghai Sixth People's Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1016/j.jot.2025.10.006
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00