End-stage pulmonary fibrosis following paraquat toxicity in a delayed presentation

Paraquat is a widely used herbicide in India. Although rare, its consumption for suicidal purposes is highly fatal due to the non-availability of an antidote. We report the case of an adolescent girl with a history of paraquat ingestion who presented 10 days later with respiratory distress and shock. She was managed with high-flow nasal oxygen, inotropes and antioxidants. High-resolution CT revealed extensive lung fibrosis, and she was recommended for evaluation for lung transplantation. This case highlights the progressive, irreversible pulmonary damage in delayed presentation of paraquat poisoning. The rarity of such presentations with visible pulmonary fibrosis progression underscores the need for better diagnostic and therapeutic guidelines and potentially aids ongoing research toward an effective antidote.

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Publication Details

Journal
BMJ Case Reports
Published
2025-12-01
DOI
https://doi.org/10.1136/bcr-2025-270578
Primary Topic
Paraquat toxicity studies and treatments
Type
article
Field-Weighted Citation Impact
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article

End-stage pulmonary fibrosis following paraquat toxicity in a delayed presentation

Ahish Dakappa, Priyanka Ojas Oza, Harini H, Ila Hirebailu Sreekanta
BMJ Case Reports
Paraquat toxicity studies and treatments
article

End-stage pulmonary fibrosis following paraquat toxicity in a delayed presentation

Ahish Dakappa, Priyanka Ojas Oza, Harini H, Ila Hirebailu Sreekanta
article en

Abstract

Paraquat is a widely used herbicide in India. Although rare, its consumption for suicidal purposes is highly fatal due to the non-availability of an antidote. We report the case of an adolescent girl with a history of paraquat ingestion who presented 10 days later with respiratory distress and shock. She was managed with high-flow nasal oxygen, inotropes and antioxidants. High-resolution CT revealed extensive lung fibrosis, and she was recommended for evaluation for lung transplantation. This case highlights the progressive, irreversible pulmonary damage in delayed presentation of paraquat poisoning. The rarity of such presentations with visible pulmonary fibrosis progression underscores the need for better diagnostic and therapeutic guidelines and potentially aids ongoing research toward an effective antidote.

BMJ Case ReportsVol. 18(12)
Kempegowda Institute of Medical Sciences (IN), M.S. Ramaiah Medical College (IN)
Good health and well-being
Openalex Percentile: Top 27%
Paraquat toxicity studies and treatments
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