Anatomical and Functional Changes After Surgical Treatment of Carpal Tunnel Syndrome: A Review

Carpal tunnel syndrome (CTS) is a common condition resulting from the compression of the median nerve within the carpal tunnel (CT), leading to sensory and motor deficits in the hand. This review synthesizes current literature on the anatomical and functional changes following surgical intervention for CTS. Surgical treatment, primarily through carpal tunnel release (CTR), has been shown to alleviate symptoms for many patients; however, variability exists regarding the extent of anatomical recovery and functional improvement. Analyzing key studies, we observe that while most patients experience significant relief from pain and sensory symptoms, some may continue to report functional limitations. The prevailing conclusion is that while surgical intervention addresses compression, the extent of anatomical recovery, such as nerve conduction velocity and morphological changes in hand structure, remains underexplored. The evidence indicates that although surgical treatment generally yields positive outcomes, it often falls within the framework of statistical analysis that relies on reported outcomes without rigorous control measures. As such, further controlled studies are necessary to better elucidate the relationship between anatomical alterations and functional recovery post-surgery. The review emphasizes the need for a comprehensive approach in future research that not only focuses on statistical outcomes but also incorporates qualitative assessments of patient functionality and anatomical restoration. Ultimately, a deeper understanding of these domains will enhance the predictive models for recovery and guide clinical practices for individuals suffering from CTS. This analysis seeks to bridge existing gaps and inspire future studies aimed at optimizing therapeutic strategies for CTS.

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Journal
Cureus
Published
2025-12-23
DOI
https://doi.org/10.7759/cureus.99904
Primary Topic
Peripheral Nerve Disorders
Type
article
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article

Anatomical and Functional Changes After Surgical Treatment of Carpal Tunnel Syndrome: A Review

Angeliki Kyriakou, Sophia Syngouna, Evangelos Tzanis, John Vlamis et al.
Cureus
Peripheral Nerve Disorders
article

Anatomical and Functional Changes After Surgical Treatment of Carpal Tunnel Syndrome: A Review

Angeliki Kyriakou, Sophia Syngouna, Evangelos Tzanis, John Vlamis, Evangelos Sakellariou, Loukia Fragkopoulou
article en

Abstract

Carpal tunnel syndrome (CTS) is a common condition resulting from the compression of the median nerve within the carpal tunnel (CT), leading to sensory and motor deficits in the hand. This review synthesizes current literature on the anatomical and functional changes following surgical intervention for CTS. Surgical treatment, primarily through carpal tunnel release (CTR), has been shown to alleviate symptoms for many patients; however, variability exists regarding the extent of anatomical recovery and functional improvement. Analyzing key studies, we observe that while most patients experience significant relief from pain and sensory symptoms, some may continue to report functional limitations. The prevailing conclusion is that while surgical intervention addresses compression, the extent of anatomical recovery, such as nerve conduction velocity and morphological changes in hand structure, remains underexplored. The evidence indicates that although surgical treatment generally yields positive outcomes, it often falls within the framework of statistical analysis that relies on reported outcomes without rigorous control measures. As such, further controlled studies are necessary to better elucidate the relationship between anatomical alterations and functional recovery post-surgery. The review emphasizes the need for a comprehensive approach in future research that not only focuses on statistical outcomes but also incorporates qualitative assessments of patient functionality and anatomical restoration. Ultimately, a deeper understanding of these domains will enhance the predictive models for recovery and guide clinical practices for individuals suffering from CTS. This analysis seeks to bridge existing gaps and inspire future studies aimed at optimizing therapeutic strategies for CTS.

CureusVol. 17(12)
National and Kapodistrian University of Athens (GR), KAT General Hospital of Attica (GR)
Good health and well-being
Openalex Percentile: Top 31%
Peripheral Nerve Disorders
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Anatomical and Functional Changes After Surgical Treatment of Carpal Tunnel Syndrome: A Review — Angeliki Kyriakou, Sophia Syngouna, et al. · Cureus (2025) | TGRS Research Map | TGRS