Rare Variants in Antisense Long Noncoding RNA–Protein-Coding Gene Overlap Regions Contribute to Obsessive-Compulsive Disorder
These results highlight the importance of rare noncoding regulatory variation in OCD genetics. The association of <i>KNCN</i>/<i>MKNK1-AS1</i> variants with OCD suggests that antisense lncRNA-protein-coding overlap regions may contribute to disease susceptibility and represent potential therapeutic targets.
Authors
- Behrang Mahjani (ORCID: https://orcid.org/0000-0001-6087-9537)
- Shelby Smout
- Seulgi Jung
- Madison Caballero
Institutions
- Karolinska Institutet (SE)
- Child Health and Development Institute (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100683
- Primary Topic
- Hereditary Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00