Phase 3 randomized trial of postirradiation chemotherapy in patients with newly diagnosed ependymoma: A report from the Children’s Oncology Group
Primary analysis showed no benefit for maintenance chemotherapy. Further follow-up is important to assess its effect on late relapses. This is the largest cohort of molecularly classified ependymomas treated on a Phase 3 randomized trial.
Authors
- Uri Tabori (ORCID: https://orcid.org/0000-0002-5019-2683)
- Shengjie Wu (ORCID: https://orcid.org/0000-0002-0402-8110)
- Nicholas K. Foreman (ORCID: https://orcid.org/0000-0003-4848-4801)
- Nyasha Chambwe (ORCID: https://orcid.org/0000-0002-2812-0122)
- Patrick R. Blackburn (ORCID: https://orcid.org/0000-0003-0658-1275)
- Andrew C. Chang (ORCID: https://orcid.org/0000-0002-9769-789X)
- A. Gajjar
- Shelly Lensing (ORCID: https://orcid.org/0000-0002-6231-9362)
- Maryam Fouladi (ORCID: https://orcid.org/0000-0002-5693-035X)
- Ruth Tatevossian (ORCID: https://orcid.org/0000-0002-1653-3026)
- Emily Owens-Pickle
- Arzu Onar-Thomas
- Tianni Zhou
- Alicia Kunin-Batson
- Michael H Handler
- Jeffrey Bennett
- Thomas E Merchant
- Holly Lindsay
- Louis El Khoury
- Sarah Leary
- Amy A Smith
- Ching Lau
- Kelsey Bertrand
- James Dalton
- Ian F Pollack
- David W Ellison
- Stephen Sands
Institutions
- Seattle Children's Hospital (US)
- St. Jude Children's Research Hospital (US)
- Nationwide Children's Hospital (US)
- Cleveland Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of South Carolina (US)
- University of San Diego (US)
- University of Washington (US)
- University of California San Diego (US)
- University of Colorado Health (US)
- Brain Tumour Research (GB)
- Connecticut Children's Medical Center (US)
- Jackson Laboratory (US)
- Children’s Clinics (US)
- University of Minnesota Medical Center (US)
- Pittsburg State University (US)
- California State University, Long Beach (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1093/neuonc/noaf285
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63