HSP90α and KLK6 Co-Regulate Stress-Induced Prostate Cancer Cell Motility
We identify a novel stress-induced extracellular network that regulates MMP-2 activity and cell motility. We identified KLK6 as a stress-induced extracellular protease leading to decreased MMP-2 activity and cellular invasion, while eHSP90α is required for the rescue of MMP-2 activity once KLK6 is neutralized.
Authors
- Raymond C. Bergan (ORCID: https://orcid.org/0000-0001-8690-4876)
- Johnny Zigmond
- Katelyn L. O’Neill
Institutions
- University of Nebraska Medical Center (US)
- Stony Brook University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-22
- DOI
- https://doi.org/10.64898/2025.12.19.695259
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health