Early Detection of White Matter Integrity Changes in Down Syndrome: The Promise of PSMD as a Sensitive Biomarker
In DS, PSMD changed approximately 10-15 years before the onset of AD symptoms and linearly increased with AD clinical stages, AD pathology, and SVD metrics. These findings underscore the potential of PSMD as a sensitive biomarker for detecting early WM alterations in adults with DS.
Authors
- Olivia Belbin (ORCID: https://orcid.org/0000-0002-6109-6371)
- Bessy Benejam (ORCID: https://orcid.org/0000-0002-6789-8615)
- Lucía Maure‐Blesa
- Laura Videla (ORCID: https://orcid.org/0000-0002-9748-8465)
- Isabel Barroeta (ORCID: https://orcid.org/0000-0003-2764-7923)
- María Carmona‐Iragui (ORCID: https://orcid.org/0000-0001-6914-2339)
- José Enrique Arriola‐Infante (ORCID: https://orcid.org/0000-0002-3298-4601)
- Sandra M. Giménez
- Alexandre Bejanin (ORCID: https://orcid.org/0000-0002-9958-0951)
- Javier Arranz (ORCID: https://orcid.org/0000-0003-0891-1215)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Daniel Alcolea
- Alberto Lleó
- María Franquesa‐Mullerat (ORCID: https://orcid.org/0009-0006-1484-7132)
- Aida Sanjuan Hernandez
- Laura Del Hoyo
- Sara E Zsadanyi
- Zili Zhao
- Susana Fernandez
- Jose Allende Parra
- Mateus Rozalem Aranha
- Íñigo Rodríguez‐Baz
- Alejandra O. Morcillo‐Nieto
- Lídia Vaqué‐Alcázar
Institutions
- Universitat Autònoma de Barcelona (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109982
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00