PM2.5 exposure and regional cortical thickness in >2,000 adults from the ENIGMA‐Environment Working Group
PM<sub>2.5</sub> was inversely associated with CTh in the STG of controls only. Age-by-exposure interactions revealed a quadratic effect of PM2.5 on CTh across the lifespan, possibly indicating biphasic exposure-related neurodegeneration, where CTh increases with early pathology and declines as neurodegeneration progresses. Discordant sex effects may reflect normal sexual dimorphism that is exacerbated by air pollution, but more work is needed to better understand these results.
Authors
- Sherezade Fuentes‐Julián
- John P. Wilson (ORCID: https://orcid.org/0000-0001-5969-0729)
- Megan M. Herting (ORCID: https://orcid.org/0000-0002-0840-4582)
- Pedro Morgado (ORCID: https://orcid.org/0000-0003-3880-3258)
- Teresa Monreal
- Yen‐Ching Chen (ORCID: https://orcid.org/0000-0002-8159-7202)
- Xinhui Wang (ORCID: https://orcid.org/0000-0002-1180-4624)
- Chi Yan Rachel Li
- Maria Picó Pérez
- Jordi Huguet (ORCID: https://orcid.org/0000-0001-8420-4833)
- Juan Domingo Gispert (ORCID: https://orcid.org/0000-0002-6155-0642)
- Aaron van Donkelaar (ORCID: https://orcid.org/0000-0002-2998-8521)
- Natàlia Vilor‐Tejedor (ORCID: https://orcid.org/0000-0003-4935-6721)
- Arcadi Segura i Navarro
- Jen‐Hau Chen (ORCID: https://orcid.org/0000-0002-7141-1582)
- Christine Löchner (ORCID: https://orcid.org/0000-0002-4766-3704)
- P. Thompson
- Siyuan Shen (ORCID: https://orcid.org/0009-0006-9295-3205)
- Kayleigh Beukes
- Randall V Martin
- Beau MacDonald
- Lauren Salminen
- Dan J Stein
Institutions
- University of Southern California (US)
- LAC+USC Medical Center (US)
- National Taiwan University (TW)
- Washington University in St. Louis (US)
- Stellenbosch University (ZA)
- Barcelonaβeta Brain Research Center (ES)
- National Yang Ming Chiao Tung University (TW)
- University of Minho (PT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_105317
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00