Platelet Transfusion Thresholds for Children Supported by Extracorporeal Membrane Oxygenation: The Extracorporeal Membrane Oxygenation Hemostatic Transfusions in Children (ECSTATIC) Feasibility Clinical Trial
Non-bleeding children on ECMO can be screened, enrolled and randomized to different platelet transfusion strategies within 24 hours of cannulation. Compliance with the protocol was excellent with significant separation in pre-transfusion platelet counts between the arms. Severe bleeding and severe clotting occurred at similar rates in both thresholds. A larger, definitive trial is feasible and needed.
Authors
- Aditya Badheka (ORCID: https://orcid.org/0000-0002-9599-0996)
- Tarif A. Choudhury (ORCID: https://orcid.org/0000-0003-3798-451X)
- Ofer Schiller (ORCID: https://orcid.org/0000-0002-4607-1133)
- Simon Stanworth (ORCID: https://orcid.org/0000-0002-7414-4950)
- Philip Charles Spinella (ORCID: https://orcid.org/0000-0003-1721-0541)
- Oliver Karam (ORCID: https://orcid.org/0000-0001-6606-1736)
- Matthew L. Paden
- Marianne E. Nellis (ORCID: https://orcid.org/0000-0002-2697-6314)
- Erika R. OʼNeil (ORCID: https://orcid.org/0000-0002-2747-7760)
- Bradley J. Barney (ORCID: https://orcid.org/0000-0002-4348-2914)
- Eran Shostak (ORCID: https://orcid.org/0000-0001-7582-2218)
- Jennifer A. Muszynski (ORCID: https://orcid.org/0000-0002-3329-8048)
- Jessica S. Alvey (ORCID: https://orcid.org/0000-0002-8543-5884)
- Jill M. Cholette
- SOLVD Investigators
- Robert A. Niebler (ORCID: https://orcid.org/0000-0002-1587-1912)
- Caroline Ozment
- Timothy M. Bahr (ORCID: https://orcid.org/0000-0002-7946-0290)
- Marisa Tucci (ORCID: https://orcid.org/0000-0001-8575-1476)
- Madhuradhar Chegondi
- Umesh Joashi
- S. Ram Kumar
- Jacques Lacroix
- Jamie Furlong-Dillard
- Jesse Bain
- Garrett Coles
- subgroups of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) on behalf of BloodNet and PediECMO
- Uri Pollak
Institutions
- University of Iowa (US)
- Morgan Stanley Children's Hospital (US)
- Nationwide Children's Hospital (US)
- Uniformed Services University of the Health Sciences (US)
- University of Pittsburgh (US)
- Duke University (US)
- Hebrew University of Jerusalem (IL)
- Medical College of Wisconsin (US)
- Cornell University (US)
- University of Utah (US)
- Wilford Hall Ambulatory Surgical Center (US)
- Hadassah Medical Center (IL)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- John Radcliffe Hospital (GB)
- Yale University (US)
- United States Air Force (US)
- The Coordinating Center (US)
- Kosair Children's Hospital (US)
- Schneider Children's Medical Center (IL)
- Golisano Children's Hospital (US)
- Norton Hospital (US)
- University of Iowa Health Care (US)
- Children's Hospital of Illinois (US)
- Children's Healthcare of Atlanta (US)
- Children's Hospital & Medical Center (US)
- Children's Hospital of Richmond at VCU (US)
- Weill Cornell Medicine (US)
- University of Health Sciences (SO)
- University of Nebraska Medical Center (US)
- Université de Montréal (CA)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1097/ccm.0000000000006995
- Citations
- 1
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.67