APOE4 carriers across neurodegenerative diseases have common systemic biological dysfunction

Our findings demonstrate that APOE4 carriage defines altered biological pathways across the plasma, CSF, and brains irrespective of diagnosis, suggesting that APOE4 carriers have systemic biological changes beyond the central nervous system. Further, APOE4 carriers' underlying biological state may be essential but not sufficient for developing neurodegenerative diseases. Lifestyle and clinical factors appear to interact with the APOE4 proteomic signature in a disease-specific manner.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_099496
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

APOE4 carriers across neurodegenerative diseases have common systemic biological dysfunction

Erik C.B. Johnson, Chad M Slawson, Jeffrey M. Burns, Artur Shvetcov et al.
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

APOE4 carriers across neurodegenerative diseases have common systemic biological dysfunction

Erik C.B. Johnson, Chad M Slawson, Jeffrey M. Burns, Artur Shvetcov, Russell H Swerdlow, Caitlin A Finney, Keenan A. Walker, Laura M Winchester, Heather M Wilkins
article en

Abstract

Our findings demonstrate that APOE4 carriage defines altered biological pathways across the plasma, CSF, and brains irrespective of diagnosis, suggesting that APOE4 carriers have systemic biological changes beyond the central nervous system. Further, APOE4 carriers' underlying biological state may be essential but not sufficient for developing neurodegenerative diseases. Lifestyle and clinical factors appear to interact with the APOE4 proteomic signature in a disease-specific manner.

Alzheimer s & DementiaVol. 21(S1)
The University of Sydney (AU), University of Kansas (US), Emory University (US), UNSW Sydney (AU), University of Oxford (GB), The University of Kansas Cancer Center (US), University of Kansas Medical Center (US), National Institute on Aging (US), Westmead Institute for Medical Research (AU), Sydney Children’s Hospitals Network (AU)
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Openalex Percentile: Top 34%
Alzheimer's disease research and treatments
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