Distinct Longitudinal Trajectories of Alzheimer’s Disease Subtypes Defined by Regional Amyloid Predominance Patterns
We found distinct longitudinal trajectories regarding both clinical progression and neurodegeneration rates among AD subtypes characterized by different patterns of amyloid predominance. Our findings suggests that an AD subtype with predominant frontal-parietal amyloid deposition may have worse prognosis compared to other subtypes, underscoring the need for subtype-specific therapeutic strategies. Further studies are required to elucidate the relationship between regional amyloid predominance patterns and progression rates of AD.
Authors
- Yu Kyeong Kim (ORCID: https://orcid.org/0000-0002-3282-822X)
- Gangwoo Kim
- Bo Kyung Sohn (ORCID: https://orcid.org/0000-0002-1444-1099)
- Jun‐Young Lee
- Yeongsoo Yoon
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Yun‐Sang Lee
- Hyejin Ahn (ORCID: https://orcid.org/0000-0002-6613-4680)
- K. Kang
- Chul‐Ho Sohn (ORCID: https://orcid.org/0000-0003-0039-5746)
- Seunghoon Lee (ORCID: https://orcid.org/0000-0001-9843-5472)
- Chung Hee Gwag
- Yoonseok Oh
- Dahyun Yi
- Dong Young Lee
- Minjae Kim
- Yisak Kim
- Kwangsoo Kim
Institutions
- Seoul National University (KR)
- Soonchunhyang University Hospital Seoul (KR)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Inje University Sanggye Paik Hospital (KR)
- Myongji Hospital (KR)
- Hanyang University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109973
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00