Increased 18F-AV1451 Retention in Soft Tissue of Patients With Progressive Supranuclear Palsy

We report 18F-AV1451 PET/MRI findings of a 56-year-old man with progressive supranuclear palsy (PSP). The images revealed multifocal 18F-AV1451 tracer uptake in both intracranial and extracranial regions, with increased retention in bilateral basal ganglia regions and scalp soft tissue. The findings may reflect systemic tau pathology and provide the clinical experience for the possible assessment of the disease severity.

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Publication Details

Journal
Clinical Nuclear Medicine
Published
2025-12-23
DOI
https://doi.org/10.1097/rlu.0000000000006251
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Increased 18F-AV1451 Retention in Soft Tissue of Patients With Progressive Supranuclear Palsy

Futao Cui, Yang Li, Xin Li, Hui Wang
Clinical Nuclear Medicine
Parkinson's Disease Mechanisms and Treatments
article

Increased 18F-AV1451 Retention in Soft Tissue of Patients With Progressive Supranuclear Palsy

Futao Cui, Yang Li, Xin Li, Hui Wang
article en

Abstract

We report 18F-AV1451 PET/MRI findings of a 56-year-old man with progressive supranuclear palsy (PSP). The images revealed multifocal 18F-AV1451 tracer uptake in both intracranial and extracranial regions, with increased retention in bilateral basal ganglia regions and scalp soft tissue. The findings may reflect systemic tau pathology and provide the clinical experience for the possible assessment of the disease severity.

Clinical Nuclear Medicine
Sichuan University (CN), West China Hospital of Sichuan University (CN), National Health Insurance Fund (RS)
Good health and well-being
Openalex Percentile: Top 31%
Parkinson's Disease Mechanisms and Treatments
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