Opposing Effects of Dietary Nitrate on Muscle Contractile Function in Fast and Slow Human Muscles
We conclude that dietary NO3- has opposing effects on the contractile properties of fast and slow human muscles, which could be due to differential changes in Ca2+ sensitivity. However, potentiation was unaltered, suggesting that this occurs independently of changes in RLC phosphorylation. Additional research will be required to determine the underlying biochemical mechanisms.
Authors
- William S. Zoughaib
- Andrew R. Coggan (ORCID: https://orcid.org/0000-0002-7723-8872)
- Richard L. Hoffman (ORCID: https://orcid.org/0000-0002-2290-3951)
- Madison J. Fry
- Ahaan Singhal
Institutions
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Medicine & Science in Sports & Exercise
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1249/mss.0000000000003932
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00