Neuronal extracellular vesicle biomarkers of dysregulated insulin signaling and Alzheimer’s disease are strongly associated in prediabetes and type 2 diabetes
In individuals with PreD/T2D, NEV-associated AD/ADRD biomarkers were more strongly associated with dysregulated insulin signaling mediators in NEVs than those in TEVs. Strong correlations were observed for NEV-associated pS636-IRS-1 and pS473-Akt with p -tau217 and Aβ<sub>42</sub>, suggesting a link between dysregulated neuronal insulin signaling and AD/ADRD pathophysiology. Future studies will determine how these relationships relate to metabolic and cognitive measures.
Authors
- Darlène Antoine (ORCID: https://orcid.org/0000-0003-4527-3910)
- Owen Carmichael
- Maja Mustapić (ORCID: https://orcid.org/0000-0003-0511-2047)
- José A. Luchsinger (ORCID: https://orcid.org/0000-0002-5886-3648)
- Marinella Temprosa (ORCID: https://orcid.org/0000-0002-9976-745X)
- Vallabh O. Shah (ORCID: https://orcid.org/0000-0002-3584-4057)
- Steven E. Kahn (ORCID: https://orcid.org/0000-0001-7307-9002)
- Pandora L. Wander (ORCID: https://orcid.org/0000-0003-3671-1464)
- Saswat Sahoo (ORCID: https://orcid.org/0000-0002-2151-9579)
- Alexander Daskalopoulos
- Dana Dabelea
- Blandine Laferrère
- Dimitrios Kapogiannis
- Tushar Dubey
Institutions
- Pennington Biomedical Research Center (US)
- Colorado School of Public Health (US)
- University of New Mexico (US)
- George Washington University (US)
- University of Washington (US)
- Columbia University Irving Medical Center (US)
- Cleveland Clinic Lerner College of Medicine (US)
- National Institute on Aging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108176
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00