Dural Ectopic Lymphatic Structures Accumulate During Aging and are Dysregulated in Neurodegenerative Diseases

Dural ELS exhibit age-, sex-, and pathology-specific dynamics, reflecting their role in CNS pathology. Their differential regulation in AD, tauopathy, and DS highlights ELS as key players in the neuroimmune interface. Future research could explore manipulating ELS formation or function to mitigate neurodegenerative processes, potentially guiding immunomodulatory therapies tailored to specific diseases or patient populations.