Developing Foundation Model for Early Detection of Alzheimer's Disease and Related Dementias (ADRD) from midlife

The superior performance of CNN is consistent with the literature and the relatively low validation loss demonstrates its generalisability. While this model is currently optimised for AD with limited features, a Transfer Learning paradigm is being employed to further train the CNN model to predict risk of other AD sub-types after including BioHermes dataset into pipeline. Future work will also explore modifications of the CNN architecture for multimodal features with explainability capabilities.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70860_106904
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Developing Foundation Model for Early Detection of Alzheimer's Disease and Related Dementias (ADRD) from midlife

Ibrahim Alqatawneh, Tamlyn Watermeyer, Samuel Danso, Poorna Gunasekera et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Developing Foundation Model for Early Detection of Alzheimer's Disease and Related Dementias (ADRD) from midlife

Ibrahim Alqatawneh, Tamlyn Watermeyer, Samuel Danso, Poorna Gunasekera, Adewale Samuel Owo, Joe Butler
article en

Abstract

The superior performance of CNN is consistent with the literature and the relatively low validation loss demonstrates its generalisability. While this model is currently optimised for AD with limited features, a Transfer Learning paradigm is being employed to further train the CNN model to predict risk of other AD sub-types after including BioHermes dataset into pipeline. Future work will also explore modifications of the CNN architecture for multimodal features with explainability capabilities.

Alzheimer s & DementiaVol. 21(S6)
Northumbria University (GB), Academic Health Science Network North East and North Cumbria (GB), University of Sunderland (GB), University of Plymouth (GB), University of Edinburgh (GB)
Partnerships for the goals
Openalex Percentile: Top 35%
Dementia and Cognitive Impairment Research
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