Developing Foundation Model for Early Detection of Alzheimer's Disease and Related Dementias (ADRD) from midlife
The superior performance of CNN is consistent with the literature and the relatively low validation loss demonstrates its generalisability. While this model is currently optimised for AD with limited features, a Transfer Learning paradigm is being employed to further train the CNN model to predict risk of other AD sub-types after including BioHermes dataset into pipeline. Future work will also explore modifications of the CNN architecture for multimodal features with explainability capabilities.
Authors
- Ibrahim Alqatawneh
- Tamlyn Watermeyer (ORCID: https://orcid.org/0000-0002-8232-5305)
- Samuel Danso (ORCID: https://orcid.org/0000-0002-9396-2107)
- Poorna Gunasekera (ORCID: https://orcid.org/0000-0002-4851-5981)
- Adewale Samuel Owo
- Joe Butler
Institutions
- Northumbria University (GB)
- Academic Health Science Network North East and North Cumbria (GB)
- University of Sunderland (GB)
- University of Plymouth (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_106904
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00