Physical activity and blood‐based biomarkers of neurodegeneration in community dwelling Australians from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease)

This study provides novel evidence for the association of physical activity with blood-based biomarkers of AD, and how APOE- ε4 presence modifies this relationship. Physical activity offers an ideal target for large-scale targeted community interventions seeking to reduce the risk of dementia and AD, as well as the biological prodrome that precedes clinical manifestation.