Capturing Alzheimer’s Disease Heterogeneity With Spatially Independent Patterns of Amyloid Accumulation

We found five cortical and four non-cortical independent components of amyloid-PET signal with high consistency between two radiotracers and which related differentially to GM volumes. This method allowed us to quantify several features that could capture heterogeneous disease processes.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70862_109907
Primary Topic
Functional Brain Connectivity Studies
Type
article
Field-Weighted Citation Impact
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article

Capturing Alzheimer’s Disease Heterogeneity With Spatially Independent Patterns of Amyloid Accumulation

Andrew Stephens, Luigi Lorenzini, Mario Tranfa, R. Vandenberghe et al.
Alzheimer s & Dementia
Functional Brain Connectivity Studies
article

Capturing Alzheimer’s Disease Heterogeneity With Spatially Independent Patterns of Amyloid Accumulation

Andrew Stephens, Luigi Lorenzini, Mario Tranfa, R. Vandenberghe, Bernard Hanseeuw, Prithvi Arunachalam, Juan Domingo Gispert, Michael Schöll, Gill Farrar, Leonard Pieperhoff, Pierre Payoux, Pieter Jelle Visser, Marta Marquié, Frederik Barkhof, Pablo Martínez‐Lage, Frank Jessen, Christopher Buckley, Henk Mutsaerts, Tiago Gil Oliveira, Mercè Boada, Giovanni B. Frisoni, Alle Meije Wink, Wiesje M. van der Flier, Craig Ritchie, Lyduine E. Collij
article en

Abstract

We found five cortical and four non-cortical independent components of amyloid-PET signal with high consistency between two radiotracers and which related differentially to GM volumes. This method allowed us to quantify several features that could capture heterogeneous disease processes.

Alzheimer s & DementiaVol. 21(S8)
Scottish Agricultural Science Agency (GB), Université Fédérale de Toulouse Midi-Pyrénées (FR), Lund University (SE), General Electric (Spain) (ES), Buckinghamshire Healthcare NHS Trust (GB), Universitat Internacional de Catalunya (ES), Maastricht University (NL), University Hospital of Geneva (CH), Pasqual Maragall Foundation (ES), Barcelonaβeta Brain Research Center (ES), Amsterdam University Medical Centers (NL), Fundacion CITA Alzheimer (ES), University Hospital Cologne (DE), University College London (GB), Geneva College (US), University of Naples Federico II (IT), Vrije Universiteit Amsterdam (NL), University of Gothenburg (SE), University of Amsterdam (NL), KU Leuven (BE), University of Minho (PT)
Openalex Percentile: Top 33%
Functional Brain Connectivity Studies
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