Discovery of an Indolizine‐Based Compound with Potent Aβ42 Disaggregation Activity
These findings identify YIAD-0708 as a promising lead compound with potent Aβ42 disaggregation activity and potential for CNS penetration. Future in vivo studies are planned to evaluate its therapeutic efficacy in AD models.
Authors
- Suhyun Ye
- Soljee Yoon (ORCID: https://orcid.org/0000-0002-5063-8921)
- S. Kwak
- Ikyon Kim (ORCID: https://orcid.org/0000-0002-0849-5517)
- Youngsoo Kim
- D.‐H. KANG
Institutions
- Incheon National University (KR)
- Yonsei University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108415
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00