Association of plasma biomarkers with longitudinal change in age‐ and Alzheimer’s disease‐related brain atrophy patterns
Among cognitively unimpaired individuals, plasma p -tau181 exhibits specificity to the risk of conversion to MCI/dementia due to AD and longitudinal change in AD-related neurodegeneration, specifically, parieto-temporal atrophy, whereas Aβ<sub>42</sub>/Aβ<sub>40</sub> and GFAP are associated with both age- and AD-related neurodegeneration.
Authors
- Jasmine Cooper
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Murat Bilgel (ORCID: https://orcid.org/0000-0001-5042-7422)
- Zhijian Yang (ORCID: https://orcid.org/0000-0002-7863-827X)
- Ishaan Shah
- Abhay Moghekar
- Susan M. Resnick
- Yang An
Institutions
- National Institutes of Health (US)
- Johns Hopkins University (US)
- University of Michigan (US)
- Johns Hopkins Medicine (US)
- National Institute on Aging (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108568
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00