Translational control by eIF2α phosphorylation and its downstream effectors in AD brains and in primary microglia exposed to Aβ or tau oligomers
Our findings indicate that eIF2α-P and its downstream signaling are not changed in microglia exposed to AβOs or TauOs. Future work is warranted to explore other mechanisms underlying mRNA translation in AD microglia.
Authors
- Luana Heimfarth (ORCID: https://orcid.org/0000-0002-4503-8905)
- Gustavo Trevizani Stelzer (ORCID: https://orcid.org/0000-0002-3605-4874)
- Mychael V. Lourenco (ORCID: https://orcid.org/0000-0002-1078-0296)
- Ottavio Arancio (ORCID: https://orcid.org/0000-0001-6335-164X)
- Mariana Gomes Chauvet
- Sérgio T. Ferreira (ORCID: https://orcid.org/0000-0001-7160-9866)
- Fernanda Guarino De Felice
- Danielle Cozachenco
- Ricardo A S Lima‐Filho
- Juliana T S Fortuna
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Queen's University (CA)
- D’Or Institute for Research and Education (BR)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098364
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00