Genetic Variation of Aquaporin‐4 Associates with Cognition, Brain Volume, and Dementia Risk in a Large Community Cohort
Carrying the minor allele at the AQP4 haplotype was associated with better episodic memory, larger hippocampal volumes, and trends for lower dementia risk. Further research exploring the role of AQP4 may identify additional mechanism contributing to dementia onset and progression.
Authors
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Stephanie Yiallourou (ORCID: https://orcid.org/0000-0002-2433-6372)
- Marina Cavuoto (ORCID: https://orcid.org/0000-0002-3874-2267)
- Dibya Himali
- Alexa S. Beiser (ORCID: https://orcid.org/0000-0001-8551-7778)
- C. S. DeCarli
- Jayandra J. Himali
- Emma Louise Palatsides
- Qiong Yang
- Matthew P. Pase
- Andrée‐Ann Baril
Institutions
- Boston University (US)
- The University of Texas at San Antonio Health Science Center (US)
- National Ageing Research Institute (AU)
- Institute for Neurodegenerative Disorders (US)
- Hôpital du Sacré-Cœur de Montréal (CA)
- The University of Texas at San Antonio (US)
- Monash University (AU)
- Université de Montréal (CA)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_097453
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00