Mitochondrial DNA copy number reduction via <i>in vitro TFAM</i> knockout remodels the nuclear epigenome and transcriptome
We demonstrate that mitochondrial DNA variation signals to the nuclear DNA epigenome and transcriptome and may lead to nuclear remodeling relevant to development, aging, and complex disease.
Authors
- Christina A. Castellani (ORCID: https://orcid.org/0000-0003-2737-0549)
- Phyo W. Win (ORCID: https://orcid.org/0009-0000-2761-0800)
- Gregory A. Newby (ORCID: https://orcid.org/0000-0001-7869-2615)
- Katie E. Hong
- Elly H. Shin (ORCID: https://orcid.org/0009-0009-6958-9259)
- Charles Newcomb (ORCID: https://orcid.org/0000-0002-2646-7288)
- Bradley P. Yates
- Emma Burke (ORCID: https://orcid.org/0009-0001-6419-5762)
- D. E. Arking
- Julia Nguyen (ORCID: https://orcid.org/0009-0009-4715-5150)
- Tyler Shin Nagano
- David E. Carter
- Brent Selimi
- Anahita M. Meybodi
Institutions
- Western University (CA)
- Lawson Health Research Institute (CA)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Robarts Clinical Trials (CA)
Publication Details
- Journal
- Epigenomics
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1080/17501911.2025.2603883
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00