Associations between Early‐Life Area‐Level Disadvantage and Plasma Markers of Alzheimer’s Disease Pathology and Neurodegeneration – A Mixed‐Longitudinal Study
Our findings suggest that addressing disparities in SDOH within the critical epoch of brain development encompassing infancy, childhood, and adolescence may hold the potential to reduce the likelihood of pathological brain changes associated with AD occurring later in life, including the accumulation of amyloid plaques, neuroinflammation, and axonal injury.
Authors
- Henrik Zetterberg
- S. M. Keller
- Jason F. Moody (ORCID: https://orcid.org/0000-0002-5854-9659)
- Rachael E. Wilson (ORCID: https://orcid.org/0000-0003-4197-7777)
- Kaj Blennow
- Amanda DeWitt (ORCID: https://orcid.org/0000-0003-3190-3475)
- William R. Buckingham
- Amy J.H. Kind
- Barbara B. Bendlin
- Sterling C Johnson
- Samriddhi Dube
- W. Ryan Powell
Institutions
- University of Wisconsin–Madison (US)
- Hong Kong Science and Technology Parks Corporation (HK)
- Sahlgrenska University Hospital (SE)
- UK Dementia Research Institute (GB)
- University of Wisconsin Health (US)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_107967
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00