Utility of Brachial Pulse Pressure and Cerebrospinal Fluid Biomarkers in Assessing White Matter Hyperintensities for Healthy Older Adults

Arterial stiffness may complement CSF biomarkers in characterizing WMH burden-a marker linked to AD/ADRD. The moderating effects of age and race highlight the need for precision approaches in assessing vascular contributions to dementia risk. Given the routine nature of blood pressure assessments, PP may serve as a scalable tool for early risk stratification in aging and dementia research.