Oesophageal Epithelial Cell‐Intrinsic <scp>MHCII</scp> Regulates Food Antigen‐Dependent Eosinophilic Esophagitis in an <scp>IFN</scp> γ‐Dependent Manner
Our results expand our understanding of oesophageal immune physiology and identify EEC-MHCII as mediating an anti-inflammatory axis that could be leveraged therapeutically.
Authors
- Eric Rodriguez-Lopez
- Melanie A. Ruffner (ORCID: https://orcid.org/0000-0002-2943-9944)
- Megha Lal (ORCID: https://orcid.org/0000-0002-9235-7255)
- Douglas L. Hill (ORCID: https://orcid.org/0000-0003-3128-3384)
- Laurence C. Eisenlohr (ORCID: https://orcid.org/0000-0002-8475-7910)
- Jarad Beers
- J. Spergel
- Yusen Zhou
- Amanda B. Muir
- Charles‐Antoine Assenmacher
- Stephen D. Carro
- Ravi Gautam
- Rachel L. Clement
Institutions
- Children's Hospital of Philadelphia (US)
- Parker Institute for Cancer Immunotherapy (US)
- College Opportunity Resources for Education (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Clinical & Experimental Allergy
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1111/cea.70205
- Citations
- 1
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- American Academy of Allergy Asthma and Immunology
- Children's Hospital of Philadelphia
- University of Pennsylvania
- American Partnership for Eosinophilic Disorders
- National Institutes of Health