Epigenomic subtyping of late‐onset Alzheimer's disease reveals distinct microglial signatures and molecular inflammatory phenotypes
These subtype-specific immune signatures provide critical insights into the molecular heterogeneity of LOAD and highlight potential therapeutic targets tailored to the immune dysregulation observed in each subtype.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- J.C. Koetsier (ORCID: https://orcid.org/0000-0002-7981-1345)
- Joshua Harvey (ORCID: https://orcid.org/0000-0001-6423-9983)
- Rachel Cavill (ORCID: https://orcid.org/0000-0002-3796-1687)
- Jennifer Imm (ORCID: https://orcid.org/0000-0002-8827-8669)
- Rick A. Reijnders (ORCID: https://orcid.org/0000-0001-7599-0385)
- Lars Eijssen (ORCID: https://orcid.org/0000-0002-6473-2839)
- Luke Weymouth (ORCID: https://orcid.org/0000-0002-1168-6015)
- Daniël van den Hove (ORCID: https://orcid.org/0000-0003-4047-3198)
- Katie Lunnon (ORCID: https://orcid.org/0000-0001-7570-6065)
- Ehsan Pishva
- Lachlan Ford MacBean
- Adam R. Smith (ORCID: https://orcid.org/0000-0001-6495-2711)
- Valentin Laroche
- Byron Creese (ORCID: https://orcid.org/0000-0001-6490-6037)
- Giulia Pegoraro (ORCID: https://orcid.org/0009-0001-5206-5303)
- Morteza P Kouhsar
- Gunter Kenis
Institutions
- University of London (GB)
- University of Pittsburgh (US)
- University of Exeter (GB)
- Maastricht University (NL)
- Brunel University of London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_099625
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00